Engraftment of autologous human keratinocytes and fibroblasts

Engraftment of autologous keratinocytes and fibroblasts is a cell-based therapeutic approach in which a patient's own skin cells are cultured and transplanted onto wounds or burns to promote regeneration of healthy, functional skin. Keratinocytes form the epidermal layer and restore the skin barrier, while fibroblasts populate the dermis and secrete extracellular matrix to support tissue structure and healing. The combination accelerates wound closure, improves re-epithelialization, and can reduce scarring by reconstituting both epidermal and dermal architecture through biological interactions that mimic native skin function. This approach does not involve targeting a single molecule or receptor but leverages synergistic effects of combined cell populations to achieve full-thickness skin regeneration.

Other names

Autologous keratinocyte and fibroblast transplantationAutologous skin grafting with keratinocytes and fibroblastsCell-based skin regenerationCultured autologous keratinocytes and fibroblasts engraftment

Physical engraftment and integration of healthy, autologous skin cells (keratinocytes/fibroblasts) into wound sites. Promotion of wound re-epithelialization and granulation tissue formation. Restoration of skin barrier function via interaction and organization of epidermal and dermal cells. Stimulation of extracellular matrix synthesis and modulation of scar formation by fibroblasts.