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Target intelligence / Profile preview
Homeobox protein engrailed-1 (EN1)
- Target
- EN1
- Molecular classification
- Transcription factor, Homeobox protein, DNA-binding protein
01
Overview
Homeobox protein engrailed-1 (EN1) is a transcription factor that contains a homeodomain, enabling it to bind specific DNA sequences and regulate gene expression. EN1 is crucial for proper formation of the apical ectodermal ridge—a key structure in limb development— and for dorsal-ventral patterning in the limb. It controls pattern formation during development of the central nervous system and regulates transcription of specific genes, such as utrophin. EN1 belongs to the homeobox family of transcription factors, is highly conserved, and is implicated in several developmental diseases and cancers.
- Other names
- Engrailed homeobox 1EN1Homeobox protein en-1Hu-En-1ENDOVESLBengrailed homolog 1
02
Biological functions
Control of embryonic developmentPattern formation of the central nervous systemDorsal-ventral patterning in limb developmentRegulation of gene transcription (RNA polymerase II-specific)
03
Disease associations
Limb-brain-type Endove SyndromeEccrine porocarcinoma (a type of skin cancer)Potential roles in developmental neurological disorders
04
Safety considerations
Therapeutic modulation of EN1 could pose risks due to its essential role in embryonic and CNS development; unintended effects could include developmental abnormalities and neurotoxicity
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