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Target intelligence / Profile preview
Enhancer of zeste homolog 1 (EZH1)
- Target
- EZH1
- Molecular classification
- Enzyme, Histone modification, Transcription factor, Methyltransferase
01
Overview
Enhancer of zeste homolog 1 (EZH1) is a histone methyltransferase and a core catalytic subunit of the Polycomb Repressive Complex 2 (PRC2). It mediates epigenetic gene silencing by catalyzing H3K27 methylation, leading to transcriptional repression. EZH1 plays a role in stem cell maintenance, tissue homeostasis, and response to injury. While primarily studied in the context of cancer, its functional redundancy/complementarity with EZH2 needs to be considered during therapeutic targeting.
- Other names
- Histone-lysine N-methyltransferase EZH1
02
Mechanism of action
H3K27 methylation leading to transcriptional repression
03
Biological functions
Transcriptional repressionChromatin compactionStem cell maintenanceRegulation of hair follicle homeostasisWound repairEpigenetic gene silencingTissue homeostasis
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to sequence similarity with EZH2Redundancy with EZH family members may limit therapeutic efficacy
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