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Target intelligence / Profile preview
Enkephalinase
- Molecular classification
- Enzyme, Peptidase, Metalloprotease, Aminopeptidase, Dipeptidylpeptidase
01
Overview
Enkephalinase refers to a group of enzymes responsible for the degradation of enkephalins, endogenous opioid peptides acting as neurotransmitters. These enzymes, including Aminopeptidase N, Neutral Endopeptidase (Neprilysin), Enkephalinase A1/A2, and Enkephalinase B, play a crucial role in regulating the physiological effects of enkephalins by controlling their breakdown and duration of action. Inhibition of these enzymes has therapeutic potential for pain management, depression/anxiety disorders, addiction, and gastrointestinal disturbances.
- Other names
- Aminopeptidase NNeutral endopeptidaseNeprilysinEnkephalinase A1Enkephalinase A2Enkephalinase B
02
Mechanism of action
Inhibition of enkephalin degradation, leading to increased enkephalin levels and enhanced opioid receptor activation
03
Biological functions
Neurotransmitter degradationOpioid peptide metabolismPain modulationRegulation of enkephalin levelsNeuropeptide processing
04
Disease associations
PainDepressionAnxietyAddictionDiarrheaReward deficiency syndrome
05
Interacting drugs
Racecadotril
3 more in the full profile.
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