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Target intelligence / Profile preview
Enolase-phosphatase 1 (ENOPH1)
- Target
- ENOPH1
- Molecular classification
- Enzyme
01
Overview
Enolase-phosphatase 1 (ENOPH1) is a bifunctional enzyme involved in the methionine salvage pathway, catalyzing both the enolization and phosphatase activities required for converting 2,3-diketo-5-methylthio-1-phosphopentane to downstream products[1][7]. It possesses acireductone synthase activity and is localized in the cytosol[5]. ENOPH1 has been identified as a potential indicator for malignant glioma, where it appears to promote cell proliferation and migration[4][5]. No known small-molecule modulators or approved drugs targeting ENOPH1 have been reported to date.
- Other names
- Enolase-phosphatase E1E1MASAMSTP145mtnC2,3-diketo-5-methylthio-1-phosphopentane phosphataseacireductone synthaseMASA homologMST145
02
Biological functions
Methionine salvage pathwayEnolization of 2,3-diketo-5-methylthiopentyl-1-phosphateAcireductone synthase activityCell proliferation (promotes cell proliferation and migration in cancer contexts)
03
Disease associations
Cancer (notably indicated as a potential malignant glioma biomarker)Other (possible implications in additional pathologies through methionine metabolism)
04
Biomarkers
Potential biomarker for malignant glioma
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