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Enoyl-[acyl-carrier-protein] reductase
- Molecular classification
- Enzyme, Reductase, Short-chain dehydrogenase/reductase (SDR) superfamily, Medium-chain dehydrogenase/reductase (MDR) superfamily
01
Overview
Enoyl-[acyl-carrier-protein] reductase (ENR, also known as FabI; EC 1.3.1.9) is a key enzyme in the type II fatty acid synthesis (FAS-II) pathway, catalyzing the final step of each elongation cycle during fatty acid biosynthesis in bacteria and plants. This reaction involves the NADH- or NADPH-dependent reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Its essential role makes it an attractive antibacterial drug target. Triclosan, triclocarban, and isoniazid inhibit bacterial ENRs at low concentrations by binding directly to their active sites.
- Other names
- Enoyl-acyl carrier protein reductaseEnoyl-ACP reductaseFabI (E. coli)InhA (M. tuberculosis)
02
Mechanism of action
Inhibition of enoyl-[acyl-carrier-protein] reductase, blocking fatty acid synthesis.
03
Biological functions
Fatty acid biosynthesisReduction of trans-2-enoyl-ACP to acyl-ACP
04
Disease associations
Infection
05
Safety considerations
Potential for resistance development in bacteriaSpecies-specific inhibitor sensitivity
06
Interacting drugs
Triclosan
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