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Target intelligence / Profile preview
Enoyl-acyl carrier protein reductase InhA (InhA)
- Target
- InhA
- Molecular classification
- Enzyme, Reductase
01
Overview
Enoyl-acyl carrier protein reductase InhA is a key enzyme in the type II fatty acid biosynthesis (FAS-II) pathway of *Mycobacterium tuberculosis* (Mtb). It catalyzes the NADH-dependent reduction of enoyl-ACP to acyl-ACP, a critical step in the elongation cycle for mycolic acid synthesis. Mycolic acids are essential components of the mycobacterial cell wall, contributing to its impermeability and pathogenicity. InhA is a clinically validated drug target for tuberculosis, inhibited by drugs like Isoniazid and Ethionamide. Mutations in inhA or overexpression can lead to drug resistance.
02
Mechanism of action
Inhibition of mycolic acid synthesis via NADH-dependent reduction of enoyl-ACP intermediates.
03
Biological functions
Fatty acid biosynthesisMycolic acid synthesisReduction of enoyl-ACP
04
Disease associations
InfectionTuberculosis
05
Safety considerations
Drug resistance (mutations in inhA or overexpression)Cross-resistance to Isoniazid and Ethionamide
06
Interacting drugs
Isoniazid
3 more in the full profile.
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