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Enteric Hormones (N/A)
- Target
- N/A
- Molecular classification
- Peptide hormones
01
Overview
Enteric hormones are a group of peptide hormones secreted by enteroendocrine (EE) cells in the gastrointestinal (GI) tract. Key hormones include GLP-1, PYY, glicentin, and oxyntomodulin. These hormones regulate digestion, glucose homeostasis, appetite, and gut motility. Their secretion is stimulated by luminal nutrients and neural signals. Altered enteric hormone profiles are implicated in metabolic diseases, making them therapeutic targets for conditions like type 2 diabetes and obesity.
- Other names
- Gut hormonesGastrointestinal hormonesIncretins
02
Mechanism of action
Various, depending on specific hormone. Includes G-protein coupled receptor activation (e.g., GLP-1R stimulation leading to cAMP/PKA signaling), modulation of gastric emptying, and central effects on hypothalamic centers.
03
Biological functions
Regulation of digestionGlucose homeostasisAppetite controlGut motilityInsulin secretionGlucagon suppressionSatiety promotion
04
Disease associations
Type 2 diabetesObesityImpaired glucose toleranceMetabolic diseases
05
Safety considerations
Potential for hypoglycemia with GLP-1 agonistsGastrointestinal side effects (nausea, vomiting)Pancreatitis (rare)
06
Interacting drugs
DPP-IV inhibitors
1 more in the full profile.
07
Biomarkers
Postprandial GLP-1 levelsFasting glucose levelsHbA1c
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