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Target intelligence / Profile preview
Enteric Nervous System (ENS)
- Target
- ENS
- Molecular classification
- Neural Network, Peripheral Nervous System, Ganglia
01
Overview
The enteric nervous system (ENS) is a complex and autonomous network of neurons and glial cells located within the walls of the gastrointestinal tract. It regulates various GI functions, including motility, secretion, blood flow, absorption, and immune responses. The ENS can operate independently from the central nervous system and contains complete reflex circuits. Dysfunction of the ENS is implicated in several gastrointestinal disorders.
- Other names
- Second brainIntrinsic nervous system of the gastrointestinal tractGut nervous system
02
Mechanism of action
Modulation of neurotransmitter release, receptor activation, or downstream signaling pathways within the enteric nervous system to influence gastrointestinal function.
03
Biological functions
Regulation of gastrointestinal motilityRegulation of gastrointestinal secretionRegulation of gastrointestinal blood flowRegulation of absorptionRegulation of immune responses in the gutIntegration of sensory information from the gut lumenLocal reflex circuits in the gut
04
Disease associations
Irritable Bowel Syndrome (IBS)Hirschsprung's diseaseChronic constipationChronic diarrheaParkinson's disease (early pathology)Gastrointestinal disorders
05
Safety considerations
Potential for off-target effects on other parts of the nervous systemVariability in ENS structure and function between individualsDifficulty in delivering drugs specifically to the ENSPotential for disruption of the gut microbiome
06
Interacting drugs
Acetylcholinesterase inhibitors
6 more in the full profile.
07
Biomarkers
Presence/absence of enteric neurons (e.g., in Hirschsprung's disease)Levels of specific neurotransmitters or neuropeptides in gut tissueEnteric glial cell markersExpression of specific receptors or enzymes within the ENS
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