Target intelligence / Profile preview

Enterococcus faecalis (E. faecalis)

Target: E. faecalis
Molecular classification: Bacterium, Gram-positive bacterium, Opportunistic pathogen

Overview

Enterococcus faecalis is a Gram-positive, facultatively anaerobic bacterium commonly found in the gastrointestinal tract of humans and animals. While typically harmless, it can become an opportunistic pathogen causing serious infections such as bacteremia, endocarditis, and UTIs, especially in immunocompromised individuals. Its virulence factors include adhesins, cytolysin, biofilm formation, and gelatinase. Notably, E. faecalis exhibits resistance to many antibiotics, complicating treatment. It can also interfere with L-DOPA metabolism.

Mechanism of action

N/A

Biological functions

Commensal organismPathogenBiofilm formationTyrosine decarboxylation

Disease associations

BacteremiaSepsisEndocarditisUrinary Tract Infection (UTI)Wound infectionSurgical site infectionMeningitis

Safety considerations

Antibiotic resistanceVancomycin resistanceHigh-level gentamicin resistanceBiofilm formation on medical devicesOpportunistic infections in immunocompromised individualsL-DOPA metabolism interference

Interacting drugs

Penicillin

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