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Target intelligence / Profile preview
Enteropeptidase (ENTK)
- Target
- ENTK
- Molecular classification
- Serine protease, Type II transmembrane serine protease
01
Overview
Enteropeptidase, also known as enterokinase, is a serine protease enzyme produced by the cells of the duodenum. It plays a crucial role in digestion by catalyzing the activation of trypsinogen into trypsin, initiating a cascade that leads to the activation of several other pancreatic digestive enzymes. Deficiency can lead to severe congenital disorders characterized by failure to thrive due to malabsorption. Conversely, inappropriate presence may contribute to pancreatitis.
- Other names
- EnterokinaseTMPRSS15PRSS7
02
Mechanism of action
Catalyzes the activation of trypsinogen to trypsin by cleaving the peptide bond after DDDDK sequence.
03
Biological functions
Activation of trypsinogenActivation of pancreatic digestive enzymesProtein digestion
04
Disease associations
Malabsorption syndromePancreatitis
05
Safety considerations
Potential for inappropriate enzyme activation leading to pancreatitisDeficiency can lead to severe malabsorption and malnutrition
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