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Target intelligence / Profile preview
Enterotoxigenic Escherichia coli (ETEC)
- Target
- ETEC
- Molecular classification
- Other (pathogenic bacterium)
01
Overview
Enterotoxigenic *Escherichia coli* (ETEC) is a pathotype of *E. coli* and one of the leading bacterial causes of diarrhea worldwide, especially in children in low-income countries and in travelers. ETEC is defined by its ability to produce heat-labile (LT) and/or heat-stable (ST) enterotoxins, which stimulate intestinal secretion of water and electrolytes, leading to watery diarrhea. ETEC also expresses a variety of colonization factors (fimbriae), facilitating attachment to the small intestinal mucosa. While not a single molecular target, ETEC's toxins and colonization antigens are being investigated as vaccine and drug targets[1][3][9][7][8].
- Other names
- ETECTraveler’s diarrhea Escherichia coliDiarrheagenic E. coli (ETEC subtype)
02
Mechanism of action
Antibiotics inhibit bacterial replication or metabolism; Vaccines induce immunity to surface antigens/fimbriae or toxins.
03
Biological functions
Diarrheagenic pathogenToxin secretion (heat-labile and heat-stable enterotoxins)Intestinal colonization
04
Disease associations
Infection (major cause of diarrhea)Traveler’s diarrheaChildhood diarrhea, particularly in low- and middle-income countries
05
Safety considerations
Antibiotic resistance is an emerging challengeNo currently licensed vaccine; supportive therapy is primaryRisks of dehydration, especially in children
06
Interacting drugs
azithromycin
3 more in the full profile.
07
Biomarkers
Presence of heat-labile (LT) and/or heat-stable (ST) enterotoxin genesColonization factor antigen (CFA/I, CS1–CS22) detection
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