Target intelligence / Profile preview

Enterotoxigenic Escherichia coli Colonization Factor Antigen 5 (CS5)

Target: CS5
Molecular classification: Fimbriae, Adhesin, Colonization Factor Antigen, CFA/IV family

Overview

Enterotoxigenic Escherichia coli (ETEC) Colonization Factor CS5 is a fimbrial adhesin that mediates the attachment of ETEC bacteria to the small intestinal epithelium. It belongs to the CFA/IV family and facilitates colonization, leading to diarrheal disease. Expression is regulated by bile salts. CS5 is a target for vaccine development to prevent ETEC infections.

Mechanism of action

N/A

Biological functions

Adhesion to intestinal epitheliumColonizationHost-pathogen interaction

Disease associations

InfectionDiarrheal diseaseEnterotoxigenic Escherichia coli infection

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