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Target intelligence / Profile preview
Enterotoxigenic Escherichia coli Colonization Factor Antigen CS3 (CS3)
- Target
- CS3
- Molecular classification
- Adhesin, Colonization Factor Antigen, Fibrillar Adhesin
01
Overview
Enterotoxigenic Escherichia coli (ETEC) Colonization Factor Antigen CS3 (CS3) is a fibrillar adhesin expressed on the surface of certain ETEC strains. It belongs to the CFA/II family and mediates the attachment of ETEC to the small intestinal epithelium, facilitating colonization and subsequent delivery of enterotoxins. CS3 is considered a promising target for vaccine development against ETEC-related diarrheal diseases.
- Other names
- Coli Surface antigen 3
02
Mechanism of action
Adhesion blocking (vaccine-induced antibodies)
03
Biological functions
Adherence to intestinal epitheliumBacterial colonizationBiofilm formation (indirectly)
04
Disease associations
InfectionDiarrheal disease
05
Safety considerations
Potential for off-target effects (vaccines)Elicitation of autoimmune responses (theoretical, for vaccines)
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