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Enterotoxigenic Escherichia coli Colonization Factor Antigen CS5
- Molecular classification
- Fimbrial protein, Colonization Factor, CFA/IV family
01
Overview
Enterotoxigenic Escherichia coli (ETEC) Colonization Factor CS5 is a fimbrial surface structure that mediates the adherence of ETEC to the intestinal mucosa, facilitating colonization and subsequent toxin delivery. It is a key virulence factor in ETEC-induced diarrhea, particularly in children in low- and middle-income countries and travelers. CS5 belongs to the CFA/IV family and is often found together with other CFs such as CS6 or CS4. It is a target for vaccine development.
- Other names
- CS5Colonization Factor Antigen 5ETEC CS5
02
Biological functions
Adhesion to small intestinal epitheliumBacterial colonizationEnterotoxin delivery
03
Disease associations
InfectionDiarrheal disease
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