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Target intelligence / Profile preview
Enterotoxigenic Escherichia coli Colonization Factor CS6 (CS6)
- Target
- CS6
- Molecular classification
- Adhesin, Colonization Factor, Glycosphingolipid-binding protein, Extracellular matrix-binding protein, Chaperone-usher pathway protein
01
Overview
CS6 is a colonization factor expressed by enterotoxigenic Escherichia coli (ETEC) that mediates bacterial attachment to the small intestinal epithelium. It is a heteropolymeric fiber composed of alternating CssA and CssB subunits, assembled via the chaperone-usher pathway. CS6 binds to sulfatide and fibronectin on host cells, facilitating colonization and subsequent diarrheal disease. It is considered an important antigen for inclusion in candidate vaccines against ETEC infections.
- Other names
- Coli surface antigen 6CSSA/B complexETEC colonization factor CS6
02
Mechanism of action
N/A
03
Biological functions
Adhesion to intestinal epitheliumColonization of small intestineEpithelial cell invasionFibronectin bindingSulfatide binding
04
Disease associations
Bacterial diarrheaEnterotoxigenic Escherichia coli (ETEC) infection
05
Safety considerations
Potential for off-target effects if antibodies or inhibitors cross-react with host proteins.Development of resistance to vaccines targeting CS6.
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