Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Enterotoxigenic Escherichia coli Heat-Labile Enterotoxin (LT)
- Target
- LT
- Molecular classification
- Toxin, AB5 toxin
01
Overview
Enterotoxigenic Escherichia coli (ETEC) heat-labile enterotoxin (LT) is a major virulence factor produced by ETEC, a leading cause of diarrheal disease. LT is an AB5 toxin that binds to ganglioside GM1 via its B subunits and delivers the A subunit into host cells. The A subunit ADP-ribosylates Gsα, leading to increased cAMP levels and fluid secretion in the gut.
- Other names
- ETEC heat-labile enterotoxinHeat-labile enterotoxinLT toxinLTA subunitLTB subunit
02
Mechanism of action
ADP-ribosylates Gsα proteins, constitutively activating adenylate cyclase, raising intracellular cAMP levels, stimulating chloride ion secretion and inhibiting sodium absorption, leading to water efflux into the intestinal lumen and diarrhea.
03
Biological functions
ADP-ribosylation of GsαActivation of adenylate cyclaseInduction of chloride secretionInhibition of sodium absorptionMucosal adjuvant
04
Disease associations
InfectionDiarrheal disease
05
Safety considerations
Induction of watery diarrheaDisruption of intestinal epithelial structure
Beyond the preview
Go deeper on Enterotoxigenic Escherichia coli Heat-Labile Enterotoxin (LT).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Enterotoxigenic Escherichia coli Heat-Labile Enterotoxin (LT).