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Target intelligence / Profile preview
Enterovirus 71 Capsid Protein (EV-A71 Capsid)
- Target
- EV-A71 Capsid
- Molecular classification
- Viral structural protein, Capsid protein
01
Overview
The Enterovirus 71 (EV-A71) capsid protein is a multi-protein complex forming the outer shell of the virus. It is composed of four structural proteins: VP1, VP2, VP3, and VP4. The capsid mediates viral entry into host cells through receptor binding (e.g., to SCARB2), encapsidates the viral genome, and undergoes conformational changes to release the genome during uncoating. As such, it is a key target for antiviral drug development.
- Other names
- EV-A71 Viral CapsidEnterovirus A71 CapsidVP1VP2VP3VP4
02
Mechanism of action
Inhibition of receptor binding, disruption of capsid assembly, stabilization of the capsid to prevent uncoating.
03
Biological functions
Viral entryReceptor bindingGenome encapsulationUncoatingImmune evasion
04
Disease associations
Hand, foot, and mouth disease (HFMD)Enterovirus A71 infectionNeurological complications (e.g., encephalitis, paralysis)
05
Safety considerations
Potential for drug resistance due to mutations in capsid proteinsOff-target effects of capsid-binding drugs
06
Interacting drugs
WIN compounds
1 more in the full profile.
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