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Target intelligence / Profile preview
Enterovirus 71 Replication (EV71 Replication)
- Target
- EV71 Replication
- Molecular classification
- Viral Replication
01
Overview
Enterovirus 71 (EV71) replication is a complex process involving viral entry, translation, polyprotein processing, replication organelle formation, and genome replication. It relies on viral proteins like proteases (2A^pro^, 3C^pro^), RNA-dependent RNA polymerase (3D^pol^), and structural proteins, as well as hijacking several host factors. Targeting steps such as viral protease activity, IRES-mediated translation, and RO biogenesis can impair virus propagation and has potential for therapeutic intervention.
- Other names
- EV71 Replication CycleEnterovirus 71 Life CycleEV71 Propagation
02
Mechanism of action
Various, depending on the target. Examples include inhibition of viral proteases (e.g., 2Apro, 3Cpro), disruption of IRES-mediated translation, and inhibition of RNA-dependent RNA polymerase (3Dpol).
03
Biological functions
Viral genome replicationViral protein synthesisViral assemblyHost cell manipulation
04
Disease associations
InfectionHand, foot, and mouth disease (HFMD)Neurological complications (e.g., encephalitis, acute flaccid paralysis)
05
Safety considerations
Off-target effects of antiviral compoundsDevelopment of drug resistancePotential for immune-mediated pathology
06
Interacting drugs
Etoposide
1 more in the full profile.
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