Enterovirus 71 viral particle (EV-A71 (for the virus; no canonical abbreviation for the viral particle specifically is standard))

The Enterovirus 71 viral particle is the structurally mature infectious form of EV-A71. It consists of an icosahedral protein shell composed of VP1–VP4 proteins, which encase the positive-sense, single-stranded RNA genome. VP1, VP2, and VP3 are externally exposed and mediate interaction with host cell receptors (SCARB2, PSGL-1), triggering cell entry and genome release through structural rearrangements of the capsid. The mature virion is the primary target of neutralizing antibodies, making the viral particle a key focus for vaccine and antiviral strategies. As a principal etiological agent of hand, foot, and mouth disease and severe neurological complications, EV-A71 viral particle constitutes a validated and high-priority antiviral therapeutic target. Key points: EV71 particle ≠ a cellular receptor; it is the virus itself. Not an enzyme, polymerase, channel, or transporter: molecular classification is "Viral particle" (virus). Targeting the viral particle means targeting the virus’s external structure (attachment, entry, capsid). Drugs and vaccines act against the viral particle, not a host protein.

Other names

EV71 viral particleEnterovirus 71 virionEV-A71 particleHuman enterovirus 71 particle

Capsid uncoating inhibition; Blocking viral attachment to host cellular receptors (e.g., SCARB2, PSGL-1, annexin II, heparin sulfate); Induction of neutralizing antibody responses via vaccine