Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Enterovirus A type 71 Capsid Protein (EV-A71 Capsid)
- Target
- EV-A71 Capsid
- Molecular classification
- Viral structural protein, Capsid protein
01
Overview
The Enterovirus A type 71 (EV-A71) capsid protein is the outer shell of the virus, composed of VP1, VP2, VP3, and VP4 proteins. It protects the viral genome, mediates attachment to host cell receptors like SCARB2 via VP1, and facilitates uncoating. VP1 is a major target for antiviral drugs that bind its hydrophobic pocket, preventing conformational changes needed for infection. Resistance can emerge through mutations in the VP1 pocket.
- Other names
- EV-A71 CapsidEnterovirus 71 CapsidEV-A71 viral capsid
02
Mechanism of action
Inhibition of capsid conformational changes required for genome release; stabilization of virion
03
Biological functions
Genome protectionCell entry mediationAntigenicityReceptor bindingUncoatingImmune evasion
04
Disease associations
InfectionHand, foot, and mouth disease (HFMD)Neurological complications associated with EV-A71 infection
05
Safety considerations
Potential for drug resistance through mutations in VP1Off-target effects of capsid-binding drugs
06
Interacting drugs
WIN 51711
1 more in the full profile.
Beyond the preview
Go deeper on Enterovirus A type 71 Capsid Protein (EV-A71 Capsid).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Enterovirus A type 71 Capsid Protein (EV-A71 Capsid).