Target intelligence / Profile preview

Enterovirus A71 Capsid Protein (None)

Target
None
Molecular classification
Viral structural protein
01

Overview

The Enterovirus A71 (EV-A71) capsid protein is the structural protein complex that forms the protective shell around the viral RNA genome. It is composed of four proteins: VP1, VP2, VP3, and VP4. VP1 is the most external and immunodominant protein, crucial for receptor binding and a key target for vaccine development. The capsid proteins mediate host cell attachment, facilitate endocytosis, and are essential for the uncoating of viral RNA upon entry into host cells.

02

Mechanism of action

Target of neutralizing antibodies

03

Biological functions

Genome encapsulation/protectionHost cell attachmentViral entryUncoatingImmune recognition
04

Disease associations

Hand, foot, and mouth disease (HFMD)Infection

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