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Enterovirus A71 capsid protein VP1

Molecular classification: Viral capsid protein, Structural protein

Overview

The Enterovirus A71 (EV-A71) capsid protein VP1 is a surface-exposed structural protein crucial for virus particle assembly, attachment to host cells (via receptors such as PSGL-1 and SCARB2), and viral entry. It contains major neutralizing epitopes, making it a primary target for vaccine development against EV-A71 related diseases like hand-foot-and-mouth disease (HFMD).

Mechanism of action

Antibody neutralization of viral entry

Biological functions

Virus particle assemblyHost cell receptor bindingViral entry/uncoatingImmune response (antigen presentation)

Disease associations

Hand-foot-and-mouth disease (HFMD)Enterovirus A71 infection

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