Enterovirus A71 capsid protein VP1 GH loop (EV-A71 VP1 GH loop)

The Enterovirus A71 (EV-A71) capsid protein VP1 GH loop is a critical surface-exposed structural element that plays a central role in viral pathogenesis and host cell entry (PubMed: 23552837). It is primarily responsible for mediating the attachment of the virus to its cellular receptors, most notably Scavenger Receptor Class B Member 2 (SCARB2) and P-selectin Glycoprotein Ligand-1 (PSGL-1), which are essential for viral internalization and uncoating (PubMed: 19575010, 19543277). Due to its high exposure on the viral surface, the GH loop is a major neutralizing epitope and a primary target for the development of vaccines and therapeutic antibodies (PubMed: 25855244). Inactivated EV71 vaccines, which are used to prevent hand, foot, and mouth disease (HFMD), rely heavily on the induction of antibodies targeting this region (PubMed: 24580462). Mutations within the GH loop can lead to significant changes in viral virulence, tissue tropism, and the ability to escape host immune responses, making it a key focus for molecular surveillance (PubMed: 22114482). Therapeutic strategies targeting this loop aim to block receptor binding sites, thereby neutralizing the virus before it can infect host cells.

Other names

EV71 VP1 GH loopEnterovirus 71 VP1 GH loopVP1 GH loop of Enterovirus A71VP1 GH loop

Neutralization of viral particles by blocking receptor binding sites and preventing viral entry into host cells.