Target intelligence / Profile preview

Enterovirus A71 Capsid Protein VP2 (None)

Target: None
Molecular classification: Capsid protein, Viral protein

Overview

Enterovirus A71's capsid protein VP2 is essential for virus assembly, host interaction via SCARB2 receptor binding/uncoating steps, immunogenicity through exposed epitopes on its loops ("puff," EF-loop), and modulation of neurovirulent potential through specific amino acid changes. Its conserved regions make it valuable both as a vaccine target/surrogate marker and as an epitope recognized by broadly neutralizing antibodies—supporting ongoing efforts toward pan-enterovirus vaccine design.

Mechanism of action

Blocking virion-receptor interactions

Biological functions

Capsid assemblyHost cell entryReceptor bindingVirulenceAntigenicity

Disease associations

Hand, foot, and mouth disease (HFMD)Neurological complicationsInfection

Biomarkers

Residues 136–150 as surrogate biomarker for vaccine potency

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