Target intelligence / Profile preview

Enterovirus A71 Capsid Protein VP3 (VP3)

Target: VP3
Molecular classification: Viral structural protein, Capsid protein

Overview

Enterovirus A71 (EV-A71) VP3 is a capsid protein that contributes to the structural integrity of the virion. It is exposed on the surface of the virion and contains conserved epitopes, making it a target for diagnostic monoclonal antibodies like mAb 10D3 and therapeutic neutralizing antibodies like IgG 5H7. While VP1 is often the primary target for vaccines, VP3's conserved regions offer potential for cross-protective immunity against diverse EV-A71 strains.

Mechanism of action

Neutralizing antibody targeting conserved epitope at amino acid position 74

Biological functions

Virion assemblyStructural integrity of viral capsidAntigen presentation

Disease associations

Hand, foot, and mouth disease (HFMD)

Interacting drugs

IgG 5H7 (neutralizing antibody)

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