Target intelligence / Profile preview

Enterovirus A71 Viral Particle (EV-A71)

Target: EV-A71
Molecular classification: Virus, Picornaviridae, Enterovirus, Non-enveloped virus

Overview

Enterovirus A71 (EV-A71) is a non-enveloped, icosahedral virus belonging to the family Picornaviridae. The viral particle measures approximately 20–30 nm in diameter and contains a single-stranded positive-sense RNA genome. The capsid is composed of VP1, VP2, VP3, and VP4 proteins. VP1 is a major immunodominant protein and key for entry. The virus uses receptors like SCARB2 and PSGL-1 to enter host cells. EV-A71 causes hand, foot, and mouth disease (HFMD) and can lead to severe neurological complications. Inactivated vaccines have been developed, but no specific antiviral drugs are approved.

Other names: EV71Enterovirus 71

Mechanism of action

N/A

Biological functions

Viral replicationInfectionHost cell entryImmune evasion

Disease associations

Hand, foot, and mouth disease (HFMD)MeningitisEncephalitisNeurological complications

Safety considerations

Rapid viral evolutionLimited treatment optionsNeurological complicationsLack of broad-spectrum antivirals

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