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Target intelligence / Profile preview
Enterovirus A71 Whole Virus Particle (EV-A71)
- Target
- EV-A71
- Molecular classification
- Virus, Picornavirus, Non-enveloped virus
01
Overview
The Enterovirus A71 (EV-A71) whole virus particle is the complete infectious form of the virus, consisting of a protein capsid and an RNA genome. It is a causative agent of hand, foot, and mouth disease (HFMD) and can lead to neurological complications. Inactivated whole-virus vaccines are used to prevent EV-A71 infection by eliciting neutralizing antibodies against multiple viral epitopes.
- Other names
- EV-A71 virionEnterovirus 71Enterovirus A71 full particlesEnterovirus A71 empty particles
02
Mechanism of action
Vaccines induce neutralizing antibodies that block viral entry and infection. Antiviral drugs (like Pleconaril) target the capsid to prevent uncoating.
03
Biological functions
Viral replicationCell entryInfectionImmune evasion
04
Disease associations
Hand, foot, and mouth disease (HFMD)MeningitisEncephalitis
05
Safety considerations
Potential for recombination/mutation leading to vaccine escapeProduction costs of inactivated whole-virus vaccinesEfficacy variations against different strains
06
Interacting drugs
Pleconaril (targets capsid, not specific to EV-A71, broad spectrum anti-picornavirus)
1 more in the full profile.
07
Biomarkers
Viral loadAntibody titers
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