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Target intelligence / Profile preview
Enterovirus D68 Capsid Protein (EV-D68 Capsid)
- Target
- EV-D68 Capsid
- Molecular classification
- Viral Structural Protein, Capsid Protein
01
Overview
The Enterovirus D68 (EV-D68) capsid is a nonenveloped, icosahedral protein shell that encases the viral positive-sense single-stranded RNA genome. The capsid is composed of 60 copies each of four structural proteins: VP1, VP2, VP3, and VP4. These proteins assemble to form a particle approximately 300 Å in diameter. VP1, VP2, and VP3 are exposed on the outer surface of the capsid, while VP4 lines the interior surface. The capsid plays a critical role in receptor binding (e.g., to sialic acids, ICAM-5, sulfated glycosaminoglycans and MFSD6), cell entry, and uncoating, making it a key target for antiviral development. The most variable region among strains is found in the external loops of the VP1 protein, which determines serotype specificity and antigenicity.
- Other names
- EV-D68 CapsidEnterovirus D68 Viral CapsidEV-D68 Structural ProteinsVP1VP2VP3VP4
02
Mechanism of action
N/A
03
Biological functions
Viral EntryGenome EncapsulationReceptor BindingImmune EvasionViral AssemblyUncoating
04
Disease associations
InfectionAcute Flaccid Myelitis (AFM)Respiratory Illness
05
Safety considerations
Potential for drug resistance due to antigenic variability, especially in VP1.The exact mechanism of AFM pathogenesis is still under investigation, so therapeutic strategies targeting the capsid must be carefully evaluated.Off-target effects on host cell proteins during entry and uncoating need to be considered.Efficacy can be limited by variable sialic acid binding affinity across EV-D68 strains
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