Target intelligence / Profile preview

Envelope Glycoprotein (HIV-1) (Env)

Target: Env
Molecular classification: Glycoprotein, Viral protein, Fusion protein

Overview

The envelope glycoprotein (Env) of HIV-1 is a trimeric complex on the viral surface that mediates entry into host cells. It is synthesized as gp160, which is then cleaved into gp120 and gp41. Gp120 binds to CD4 and coreceptors CCR5 or CXCR4, while gp41 mediates membrane fusion. Env is a major target for neutralizing antibodies and entry inhibitors.

Other names: gp160gp120gp41

Mechanism of action

Inhibition of receptor binding or membrane fusion

Biological functions

Viral entryReceptor bindingMembrane fusionImmune evasion

Disease associations

InfectionHIV-1 infectionAIDS

Safety considerations

High sequence variabilityGlycan shieldingConformational maskingDrug resistance

Interacting drugs

Maraviroc

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