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Envelope Glycoprotein gp120 (HIV-1), V2 Loop Deleted (gp120 ΔV2 Loop)
- Target
- gp120 ΔV2 Loop
- Molecular classification
- Glycoprotein, Viral Envelope Protein
01
Overview
Envelope glycoprotein gp120, with a deletion in the V2 loop, is a modified form of the HIV-1 gp120 protein. The V2 loop deletion enhances exposure of conserved neutralization epitopes, making it more susceptible to broadly neutralizing antibodies. This variant is used to study epitope accessibility and design immunogens for HIV vaccine development.
- Other names
- gp120 V2 deletion mutantHIV-1 gp120 ΔV2V2 loop deleted gp120
02
Mechanism of action
N/A - This is a modified viral protein used for research and vaccine development, not a drug target itself. The goal is to elicit antibodies that can neutralize the virus.
03
Biological functions
Viral entry into host cellsCD4 receptor bindingCCR5/CXCR4 coreceptor bindingMembrane fusion
04
Disease associations
HIV-1 infectionAIDS pathogenesisImmune evasion
05
Safety considerations
Potential for off-target effects if used in immunotherapyRisk of immune escape mutations
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