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Target intelligence / Profile preview
Envelope Glycoprotein gp140 (gp140)
- Target
- gp140
- Molecular classification
- Viral Envelope Glycoprotein
01
Overview
The envelope glycoprotein gp140 is a recombinant, soluble form of the HIV-1 envelope spike protein. It is derived from the precursor polyprotein gp160, which is cleaved into gp120 and gp41. Gp140 consists of gp120 covalently linked to most or all of the ectodomain portion of gp41, lacking the transmembrane and cytoplasmic regions. It mediates viral entry by binding to CD4 receptors and coreceptors, triggering membrane fusion. Gp140 is a major target for neutralizing antibodies and is used as a candidate immunogen in vaccine studies.
- Other names
- HIV-1 gp140gp120/gp41 complex (soluble ectodomain)SOSIP-gp140
02
Mechanism of action
Target of neutralizing antibodies; used in vaccine design to elicit broadly neutralizing antibodies.
03
Biological functions
Viral entryReceptor binding (CD4)Coreceptor binding (CCR5, CXCR4)Membrane fusionAntigen presentation
04
Disease associations
HIV infectionAIDS pathogenesis
05
Safety considerations
Glycosylation hindering antibody recognitionStructural instability (addressed through stabilization strategies)Potential for off-target immune responses in vaccine applications
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