Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Envelope Glycoprotein gp41 (HIV-1) (gp41)
- Target
- gp41
- Molecular classification
- Viral Fusion Protein, Envelope Glycoprotein
01
Overview
The envelope glycoprotein gp41 is a critical component of the HIV-1 envelope spike complex, which also includes gp120. Together, these proteins mediate the virus's entry into host cells. Gp41 is the transmembrane subunit responsible for catalyzing fusion between the viral and cellular membranes after initial attachment by gp120. After HIV binds to CD4 and coreceptor on target cells via gp120, conformational changes expose and activate gp41. Gp41 undergoes dramatic structural rearrangements to facilitate membrane fusion.
02
Mechanism of action
Inhibition of six-helical bundle formation, blocking membrane fusion
03
Biological functions
Viral entry into host cellMembrane fusion
04
Disease associations
InfectionHIV-1 infection
05
Safety considerations
Development of resistance to fusion inhibitors
06
Interacting drugs
Enfuvirtide (T20)
Beyond the preview
Go deeper on Envelope Glycoprotein gp41 (HIV-1) (gp41).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Envelope Glycoprotein gp41 (HIV-1) (gp41).