Enzyme cofactor for amino acid metabolism

"Enzyme cofactor for amino acid metabolism" encompasses several distinct small molecules, mainly vitamin-derived organic cofactors (such as **pyridoxal phosphate** [vitamin B6], **tetrahydrofolate** [vitamin B9], **cobalamin** [vitamin B12], and **tetrahydrobiopterin**), as well as inorganic ions, which are required for a wide variety of enzymatic steps in amino acid catabolism, biosynthesis, transamination, and one-carbon transfer reactions[1][2][3]. These cofactors are essential for stabilizing reaction intermediates, enabling electron and group transfers, and ensuring complete metabolism of amino acids for energy, biosynthesis, and waste removal. Deficiencies in these cofactors can cause serious metabolic diseases, neurological disorders, or impact cancer and cardiovascular risk through effects on methylation and amino acid homeostasis[1][2]. **Note:** This entry is too generic or broad to correspond to a single canonical therapeutic target or target class. "Enzyme cofactor for amino acid metabolism" refers to a *chemical function* rather than a protein or gene. For structured data, individual cofactors (e.g., "pyridoxal phosphate," "tetrahydrofolate") should be treated as distinct entries.

Other names

Cofactor for amino acid metabolismEnzyme cofactor (amino acid)

Cofactor supplementation restores or maintains enzyme activity Antifolates (e.g., methotrexate) inhibit folate-dependent enzymes Some drugs act by modulating or blocking use of specific cofactors in metabolic pathways