Enzyme Synthesis in Fasciola Species

Enzyme synthesis in *Fasciola* species (notably *Fasciola hepatica* and *F. gigantica*) is central to the parasite’s survival, pathogenicity, and interaction with its host. Key enzymes include cathepsin L proteases (CL1, CL3), enolase, and components of the thiol-dependent antioxidant cascade (TGR, Trx, Prx). These enzymes facilitate host tissue penetration, nutrient digestion, immune evasion, and redox balance. Some secreted enzymes are antigenic, making them useful for diagnostics or vaccine development. Inhibitors targeting cathepsins show promise as fasciolicides, and surface-exposed enzymes like enolase are potential vaccine candidates.

Other names

Fasciola hepatica enzyme productionFasciola gigantica enzyme production

Inhibition of cysteine proteases