Enzymes and proteins

The term 'Enzymes and proteins' represents a broad classification of biological macromolecules rather than a discrete therapeutic target. Proteins are essential polymers of amino acids that provide structural integrity, facilitate molecular transport, and mediate cellular signaling (MedlinePlus, NIH, 2021). Enzymes, a specific class of proteins, function as biological catalysts that lower activation energy to accelerate vital biochemical reactions (Cleveland Clinic, 2023). In the context of drug discovery, this designation is considered 'too broad' because it lacks the specificity required to define a mechanism of action or a therapeutic window. Effective drug development requires the identification of specific protein isoforms or enzymatic pathways—such as specific kinases or proteases—to ensure selectivity and minimize off-target effects (Nature Education, 2014). Consequently, while enzymes and proteins are the primary subjects of pharmacology, the category itself does not constitute a single target for drug interaction.

Other names

Proteins and enzymesBiomacromoleculesEnzymeProtein

Not applicable. This entry refers to a broad category of biological molecules rather than a specific therapeutic target.