Enzymes in DNA synthesis

"Enzymes in DNA synthesis" encompass a group of proteins required for the accurate and efficient replication and repair of DNA. Major enzyme classes include DNA polymerases (responsible for synthesizing new DNA strands), helicases (unwinding the double helix), primases (synthesizing short RNA primers), ligases (joining DNA fragments), topoisomerases (relieving torsional stress), and nucleases (removing nucleotides or processing DNA ends)[5][7][9]. These enzymes are critical for cell proliferation and genome integrity and are frequent targets in cancer chemotherapy and antiviral therapy, largely through inhibition of DNA polymerases or synthesis of nucleotides[2][3][5]. Because this term covers numerous distinct proteins belonging to different molecular families, it is overly broad for use as a canonical drug target[1][3][5]. To retrieve structured information for a specific target, such as "DNA polymerase delta," "Thymidylate synthase," or "Topoisomerase II alpha," use the precise full name of the enzyme.

Other names

DNA synthesis enzymesreplication enzymesDNA replication enzymes

Inhibition of DNA polymerase activity; Incorporation of chain-terminating analogs; Inhibition of nucleotide synthesis