Eosinophil granule ontogeny transcript (EGOT)

Eosinophil granule ontogeny transcript (EGOT) is a long non-coding RNA (lncRNA) gene located antisense within an intron of the ITPR1 gene. It is most highly expressed during early eosinophil development, where it regulates the transcript levels of major basic protein (MBP) and eosinophil-derived neurotoxin (EDN), proteins essential to eosinophil function[5][3]. EGOT has been experimentally shown not to associate with ribosomes and functions as a regulatory RNA, possibly via forming RNA-protein complexes or acting as a natural siRNA[3][5]. Beyond hematopoietic differentiation, EGOT acts as a suppressor in glioma: overexpression inhibits glioma cell proliferation and migration and induces apoptosis[1]. In renal tubular cells, decreased EGOT promotes autophagy during hypoxic stress, with EGOT regulated post-transcriptionally by the RNA-binding protein HuR[2]. Thus, EGOT is a regulatory lncRNA implicated in cancer biology, autophagy, and immune cell differentiation, but it is not considered a classical therapeutic target such as a receptor, enzyme, or transporter.

Other names

EGONCRNA00190eosinophil granule ontogenynon-protein coding RNA 190EGO-BEGO-A

Acts as a transcriptional regulator for granule protein genes (such as major basic protein [MBP] and eosinophil-derived neurotoxin [EDN]); May function as a natural siRNA or RNA-protein complex; Interacts with RNA-binding protein HuR to modulate autophagy-related gene expression