EP300 antisense RNA 1 (EP300-AS1)

EP300 antisense RNA 1 (EP300-AS1) is a long non-coding RNA (lncRNA) transcribed antisense to the EP300 gene, located on chromosome 22[3][6]. Unlike protein-coding genes, EP300-AS1 does not encode a protein but is involved in the epigenetic regulation of gene expression via interactions with proteins such as PTBP1 and transcription factors like TFAP2C[2][4][6]. Experimental evidence suggests that EP300-AS1 acts as a tumor suppressor in several cancers, including non-small-cell lung cancer and nasopharyngeal carcinoma, where it can inhibit cell proliferation, migration, and invasion, and promote apoptosis[2][4][6]. Its regulatory functions include destabilizing PRMT5 mRNA through PTBP1 interaction and modulating CST6 expression via TFAP2C interaction, thereby influencing cell growth, metastasis, and cell cycle[2][4][6]. EP300-AS1 expression may also serve as a diagnostic biomarker in certain cancers due to its differential expression in tumor versus normal tissues[4][6]. As a regulatory lncRNA, EP300-AS1 represents a promising target for cancer prediction and therapy, although it is not currently targeted by any known drugs and its safety profile is undefined.

Other names

EP300-AS1RP1-85F18.6