EP300-interacting inhibitor of differentiation 1 (EID1)

EP300-interacting inhibitor of differentiation 1 (EID1) is a **short-lived nuclear protein (187 amino acids)** that functions as a transcriptional regulator by binding to the retinoblastoma tumor suppressor protein (pRB) and transcriptional coactivators p300/CBP[2]. Through these interactions, EID1 inhibits the transcriptional activity of p300/CBP, counters cellular differentiation, and contributes to the regulation of cell cycle progression, DNA repair, and chromosomal maintenance[2]. EID1 protein's abundance is controlled via ubiquitin-mediated proteasomal degradation, notably by an SCF complex containing the F-box protein FBXO21, with its rapid turnover helping tightly control its regulatory effects[2]. EID1's biological roles and regulatory mechanisms position it as a node linking tumor suppressor, epigenetic, and transcriptional pathways, with emerging but as yet unexploited therapeutic potential in cancer biology[2].

Other names

C15orf3CRI1RBP21PNAS-22PTD014EID-121 kDa pRb-associated proteinCREBBP/EP300 inhibitory protein 1E1A-like inhibitor of differentiation 1NB4 apoptosis related proteinRb- and p300-binding protein EID-1retinoblastoma protein-associated protein

Drugs (if developed) would likely act by modulating protein stability (e.g., inhibiting EID1 function via stabilization/destabilization), protein-protein interactions, or gene transcription repression; no direct drugs known currently[2]