EP300 interacting inhibitor of differentiation 2 (EID2)

EP300 interacting inhibitor of differentiation 2 (EID2) is a human nuclear protein encoded by the EID2 gene located on chromosome 19q13.2. EID2 functions primarily as a transcriptional repressor by binding and inhibiting the histone acetyltransferase activity of EP300 (p300), a key chromatin regulator, and by interacting with class I histone deacetylases (HDACs). EID2 also interacts with Smad proteins, especially Smad3, acting as a key suppressor of TGF-beta/Smad transcriptional responses. Through these activities, EID2 is involved in the negative regulation of cell differentiation, muscle-specific gene expression (via inhibition of MyoD-dependent transcription), and the control of cell cycle regulators p21 and p15. EID2 expression is developmentally regulated and displays high levels in adult heart and brain. While not yet a direct therapeutic target, its modulation of differentiation, chromatin, and signaling pathways places it at the intersection of key regulatory networks relevant to development and disease.

Other names

EID2CRI2

Potential small molecule or biological inhibitors would be expected to modulate EP300 acetyltransferase activity, TGF-beta/Smad signaling, or MyoD-dependent transcription by disrupting EID2–target interactions or EID2 expression