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Target intelligence / Profile preview
EPH receptor A3 (EphA3)
- Target
- EphA3
- Molecular classification
- Receptor tyrosine kinase, Eph/ephrin family
01
Overview
EPH receptor A3 (EphA3) is a receptor tyrosine kinase that belongs to the Eph/ephrin family. It binds primarily to ephrin-A ligands and plays crucial roles in developmental processes, particularly in the nervous system. EphA3 mediates cell shape and movement through cytoskeletal reorganization and changes in cell-cell/cell-substrate adhesion. It is overexpressed in several cancers, including glioblastoma multiforme (GBM), making it an attractive target for specific drug delivery strategies.
- Other names
- ephrin type-A receptor 3EPHA3
02
Mechanism of action
Tyrosine kinase inhibition; targeted drug delivery (via internalization)
03
Biological functions
Signal transductionCell adhesionCell migrationEmbryonic developmentTissue patterningMorphogenesis
04
Disease associations
CancerGlioblastoma Multiforme (GBM)
05
Safety considerations
Potential for off-target effects due to expression in normal tissues (though generally low)Immunogenicity of targeted therapies
06
Biomarkers
EphA3 expression in tumor tissueEphA3 expression in tumor-associated immune cells
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