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Target intelligence / Profile preview
EPH Receptor Family Kinase (EPH Receptors)
- Target
- EPH Receptors
- Molecular classification
- Receptor, Receptor Tyrosine Kinase (RTK), Kinase
01
Overview
The EPH receptor family comprises the largest group of receptor tyrosine kinases (RTKs), with at least 15 distinct members identified in humans. These receptors play critical roles in cell positioning, migration, tissue patterning, axon guidance, and angiogenesis during development and disease processes. Activation requires direct cell-cell contact and leads to bidirectional signaling, influencing both receptor-expressing and ligand-expressing cells. Dysregulation is implicated in various cancers, making them therapeutic targets.
- Other names
- Eph receptorsEPH receptor tyrosine kinasesEphA receptorsEphB receptors
02
Mechanism of action
Inhibition of ligand binding or kinase activity, blocking downstream signaling pathways
03
Biological functions
Cell positioningCell migrationTissue patterningAxon guidanceAngiogenesisSynaptic plasticityImmune system modulationSignal transduction
04
Disease associations
CancerDevelopmental disorders
05
Safety considerations
Potential for off-target effects due to family member similarityComplex and context-dependent signaling roles
06
Interacting drugs
Peptides inhibiting ligand binding
1 more in the full profile.
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