Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Ephrin-A2 (EFNA2)
- Target
- EFNA2
- Molecular classification
- Ligand (membrane-anchored via glycosylphosphatidylinositol, not a receptor or enzyme), Ephrin family
01
Overview
Ephrin-A2 is a member of the ephrin family of proteins and is encoded by the EFNA2 gene. It acts as a ligand for Eph receptor tyrosine kinases, especially those in the EphA subclass. Ephrin-A2 is anchored to the cell membrane by a glycosylphosphatidylinositol (GPI) linkage. The ephrin–Eph signaling system is crucial for embryonic development, particularly for the nervous system, and mediates functions such as cell adhesion, migration, and axon guidance. Unlike Eph receptor A2 (EPHA2), which is a prominent therapeutic target in cancer and other diseases, Ephrin-A2 itself is not commonly the direct target for drug development. Note: If seeking the structure, function, or drug-target information for "Ephrin A2," the therapeutic target is more accurately "Eph receptor A2" (EPHA2) and not the ligand "Ephrin-A2."
- Other names
- ephrin type-A2EFNA2ephrin-A2 ligand
02
Biological functions
Axon guidanceCell migrationCell adhesionDevelopmental process mediation (especially in the nervous system)
03
Disease associations
Neurodevelopmental disordersCancer (via modulation of cell–cell signaling)
Beyond the preview
Go deeper on Ephrin-A2 (EFNA2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Ephrin-A2 (EFNA2).