Ephrin-B2

Ephrin-B2 is a cell surface transmembrane ligand encoded by the EFNB2 gene. It belongs to the ephrin-B class and primarily interacts with Eph receptors, a family of receptor tyrosine kinases. Ephrin-B2 plays crucial roles in angiogenesis by regulating endothelial cell proliferation, migration, and vessel remodeling. It mediates bidirectional signal transduction—acting as both ligand and signaling molecule itself. In the context of disease, ephrin-B2 is associated with several processes including cancer progression, neural development, and cardiovascular homeostasis. Additionally, ephrin-B2 serves as a functional cell entry receptor for Hendra and Nipah viruses. Due to its central role in multiple essential biological pathways, ephrin-B2 is a recognized therapeutic target, but efforts to modulate its activity must carefully consider potential systemic effects and safety challenges[1][2][3][4][6].

Other names

EFNB2EFNB class ephrin[2][6]ephrinB2ephrin B2

Antagonism of Eph/ephrin interaction—blocking ligand-receptor binding and downstream signal transduction[3]; Inhibition of angiogenesis by disrupting Ephrin-B2/Eph receptor signaling[1]; Blocking viral entry (potential application for inhibitors in Hendra/Nipah viral infection)[2][3]