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Target intelligence / Profile preview
Ephrin Family of Receptor Tyrosine Kinases (Eph RTKs)
- Target
- Eph RTKs
- Molecular classification
- Receptor Tyrosine Kinase, Receptor, Kinase
01
Overview
The Ephrin family of tyrosine kinases (Eph receptors) comprises the largest subfamily of receptor tyrosine kinases (RTKs). These receptors bind membrane-bound ephrin ligands on adjacent cells, mediating bidirectional signaling crucial for diverse processes like embryonic development, tissue patterning, cell migration, axon guidance, and immune function. Dysregulation is implicated in cancer and other diseases.
- Other names
- Eph receptorsErythropoietin-producing hepatocellular carcinoma receptorsEphA receptorsEphB receptors
02
Mechanism of action
Modulation of receptor tyrosine kinase activity via ligand binding, dimerization, and downstream signaling pathways (Rho GTPases, MAPK/ERK, PI3K/Akt/mTORC1, Src/Abl, Jak/STAT).
03
Biological functions
Embryonic pattern formationAxon pathfindingAngiogenesisVascular remodelingImmune cell positioningCell migrationCell adhesionSignal transduction
04
Disease associations
CancerBone diseasesNeurological disordersImmune disorders
05
Safety considerations
Off-target effects due to broad expression patternsPotential for paradoxical effects (e.g., promoting tumor growth in some contexts)Vascular toxicityImmunogenicity of targeted therapies
06
Biomarkers
Eph receptor expression levels in tumor tissueEphrin ligand expression levels in tumor microenvironmentPhosphorylation status of Eph receptorsExpression of downstream signaling molecules
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