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Target intelligence / Profile preview
Ephrin Receptor A2 (EphA2)
- Target
- EphA2
- Molecular classification
- Receptor tyrosine kinase
01
Overview
Ephrin receptor A2 (EphA2) is a receptor tyrosine kinase involved in cell migration, adhesion, proliferation, and differentiation. It interacts with ephrin-A ligands and plays a crucial role in developmental processes and tissue homeostasis. EphA2 is frequently overexpressed in various cancers, promoting tumor growth and metastasis. It also serves as an entry point for certain viruses and can contribute to drug resistance. Targeting EphA2 is being explored as a therapeutic strategy.
- Other names
- EPH receptor A2Epithelial cell kinase (ECK)Tyrosine-protein kinase receptor ECK/MPK-5/SEK-2/Myk2ephrin type-A receptor 2
02
Mechanism of action
Agonist-mediated receptor activation, Receptor inhibition via small molecules, Aptamer targeting
03
Biological functions
Cell migrationCell adhesionCell proliferationCell differentiationRegulation of developmental processesTissue boundary formation
04
Disease associations
CancerViral infection
05
Safety considerations
Drug resistancePotential for off-target effects
06
Interacting drugs
Doxazosin
2 more in the full profile.
07
Biomarkers
EphA2 overexpression in cancerEphA2 mutations in cancer
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