Ephrin type-B receptor 2 (EPHB2) (EPHB2)

Ephrin type-B receptor 2 (EPHB2) is a transmembrane protein belonging to the receptor tyrosine kinase (RTK) family, specifically the Eph receptor subgroup [1]. It plays a fundamental role in developmental biology, guiding axon pathfinding, regulating cell migration, and maintaining tissue boundaries through bidirectional signaling with its ephrin-B ligands [2]. In the adult brain, EPHB2 is critical for maintaining synaptic plasticity and long-term potentiation, and its downregulation is associated with cognitive decline in Alzheimer's disease [3]. In the context of oncology, EPHB2 exhibits a dual role; it often acts as a tumor suppressor in early-stage colorectal cancer but can promote invasion and metastasis in other malignancies like glioblastoma [4]. Therapeutic targeting of EPHB2 involves small molecule inhibitors like dasatinib, which target its kinase domain, as well as emerging RNA-based therapies designed to modulate EPHB2 mRNA levels [5]. Understanding the context-specific expression of EPHB2 is essential for developing effective precision medicine strategies in both neurology and oncology [6].

Other names

DRTERKHEK5EPHT3Tyro5Eph receptor B2

Inhibition of the tyrosine kinase activity of the EphB2 receptor to block downstream signaling pathways; alternatively, degradation of EPHB2 mRNA via antisense oligonucleotides or RNA interference to prevent protein translation [1, 5].