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Ephrin type-B receptor 4 (EPHB4)

Target: EPHB4
Molecular classification: Receptor tyrosine kinase, Eph receptor

Overview

Ephrin type-B receptor 4 (EPHB4) is a receptor tyrosine kinase involved in vascular development and angiogenesis. It mediates bidirectional signaling upon binding to ephrin-B2, regulating cell adhesion, migration, and proliferation. Dysregulation of EPHB4 is implicated in cancer and vascular malformations, making it a therapeutic target.

Other names: Hepatoma transmembrane kinaseTyrosine protein kinase TYRO11Developmental kinase 2MDK2

Mechanism of action

Inhibition of EPHB4 receptor tyrosine kinase activity.

Biological functions

Vascular developmentAngiogenesisCell migrationCell adhesionCell proliferationSignal transduction

Disease associations

CancerVascular malformationsNeointimal hyperplasia

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