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Target intelligence / Profile preview
Epidermal Growth Factor-like Domain 7 (EGFL7)
- Target
- EGFL7
- Molecular classification
- Secreted protein, Growth factor-like protein
01
Overview
Epidermal growth factor-like domain 7 (EGFL7) is a secreted protein primarily expressed in endothelial cells. It plays a significant role in angiogenesis, vasculogenesis, and neurogenesis. Overexpressed in some cancers, it promotes metastasis and is a potential therapeutic target.
- Other names
- NEU1VE-STATINZNEU1EGF like domain multiple 7
02
Mechanism of action
Inhibits PDGF-BB-induced smooth muscle cell migration, promotes endothelial cell migration, antagonizes Notch signaling
03
Biological functions
AngiogenesisVasculogenesisNeurogenesisEndothelial cell migrationModulates Notch signaling
04
Disease associations
CancerHepatocellular carcinoma (HCC)Metastasis
05
Safety considerations
Modulation of angiogenesis can have unintended consequencesPotential impact on neural stem cell differentiation
06
Biomarkers
HCC prognosis
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